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  1. All the Virology on the WWW - Virology Glossary
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  3. Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development

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View all Learn More Submit your manuscript. Scope Virology accepts submissions on major advancements in the understanding of viruses that infect bacteria, archaea, fungi, plants or animals, and strives to cover topics both basic and applied. Read More. Editorial Board. This section has no chief editors. View all Apply. Research Topics. The Ackermann book is organized according to the genomic type of the viruses. These books form the foundation of this course. Other resources, including on-line material, provide the necessary details to build a complete picture.

There is latitude for each student to choose among the references to best suit their needs and interests. First of all, use more than one approach. The more ways you experience the information, the easier it is to remember and understand. Experiment and use what works best. Some of my suggestions may seem awkward or time-consuming at first, but with practice, they are well worth the effort.

How you concept map is largely up to you. Some like to start with a huge piece of paper, then let the map grow as the semester progresses. Then they link these smaller maps together in different ways- sort of like a dynamic puzzle. Many use different colors- some freely as the mood strikes; others develop a legend, with each color assigned a meaning. Some add illustrations. Others make diagrams. Still others make lists or tables.

Be creative and have fun with it. Review your underlining or notes on a schedule similar to reviewing lecture notes. Incorporate material from your reading into the concept maps. The organization of this course is designed to support most learning styles. Pre-reading on your part is important for both lectures and discussion sections. Genetic diversity among Lassa virus strains.

Lukashevich, I. Vaccine platforms to control Lassa fever. Expert Rev. Brunotte, L. Domain structure of Lassa virus L protein. Morin, B. PLoS Pathog. Loureiro, M. Molecular determinants of Arenavirus Z protein homo-oligomerization and L polymerase binding. Capul, A. Conserved residues in Lassa fever virus Z protein modulate viral infectivity at the level of the ribonucleoprotein.

Wilda, M. Mapping of the Tacaribe Arenavirus Z-protein binding sites on the L protein identified both amino acids within the putative polymerase domain and a region at the N terminus of L that are critically involved in binding. Perez, M. Lenz, O. Eschli, B. Identification of an N-terminal trimeric coiled-coil core within arenavirus glycoprotein 2 permits assignment to class I viral fusion proteins. Hastie, K. Structural basis for antibody-mediated neutralization of Lassa virus. Science , — Shimojima, M.

Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. The search for animal models for Lassa fever vaccine development. Advanced vaccine candidates for Lassa fever.

All the Virology on the WWW - Virology Glossary

Viruses 4 , — Peters, C. Experimental studies of Arenaviral hemorrhagic fevers. Jahrling, P. Endemic Lassa fever in Liberia. Characterization of Lassa virus isolates. Safronetz, D. The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset. Hensley, L. Pathogenesis of lassa fever in cynomolgus macaques. Baize, S. Early and strong immune responses are associated with control of viral replication and recovery in Lassa virus-infected cynomolgus monkeys.

Lassa virus hepatitis: a study of fatal Lassa fever in humans. Morrison, H. Protection of guinea pigs from lassa fever by vaccinia virus recombinants expressing the nucleoprotein or the envelope glycoproteins of lassa virus. Virology , — Malhotra, S. Transcriptional profiling of the circulating immune response to Lassa virus in an aerosol model of exposure.

Caballero, I. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. Zapata, J. Walker, D. Comparative pathology of Lassa virus infection in monkeys, guinea-pigs, and Mastomys natalensis. World Health Organ. Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells. Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages. Microbes Infect. Hawiger, D. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.

Lee, A. Pathogenesis of Lassa fever virus infection: I. Detection of Lassa virus antinucleoprotein immunoglobulin G IgG and IgM antibodies by a simple recombinant immunoblot assay for field use. Hummel, K. Baculovirus expression of the glycoprotein gene of Lassa virus and characterization of the recombinant protein. Virus Res. Lloyd, G. Identification of Lassa fever virus infection with recombinant nucleocapsid protein antigen. Lancet , Ruo, S.

Antigenic relatedness between arenaviruses defined at the epitope level by monoclonal antibodies. Hufert, F. Epitope mapping of the Lassa virus nucleoprotein using monoclonal anti-nucleocapsid antibodies.

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  • Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Endemic lassa fever in liberia. Selection of optimally effective plasma for treatment by passive immunization. Protection of lassa virus-infected guinea pigs with lassa-immune plasma of guinea pig, primate, and human origin. Passive antibody therapy of Lassa fever in cynomolgus monkeys: importance of neutralizing antibody and Lassa virus strain. Cross, R.

    Virology Lectures 2016 #1: What is a virus?

    Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies. Johnson, K. Clinical virology of Lassa fever in hospitalized patients. Grove, J. Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report. Lunkenheimer, K. Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. Towner, J.

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    Drosten, C. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, rift valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. Panning, M. Laboratory diagnosis of Lassa fever, Liberia. Vieth, S. Olschlager, S. Rapid and specific detection of Lassa virus by reverse transcription-PCR coupled with oligonucleotide array hybridization. Leski, T. Sequence variability and geographic distribution of Lassa virus, Sierra Leone.

    Fukuma, A. Testing and validation of high density resequencing microarray for broad range biothreat agents detection. Jones, A. Development of a handheld multiplex point of care diagnostic for differentiation of Lassa fever, dengue fever, and Ebola hemorrhagic fever. Niklason, L. Functional arteries grown in vitro. Shaffer, J. Lassa fever in post-conflict Sierra Leone.

    Sogoba, N. Diagnosis and clinical virology of Lassa fever as evaluated by enzyme-linked immunosorbent assay, indirect fluorescent-antibody test, and virus isolation. Emmerich, P. Branco, L. Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection. Lassa hemorrhagic fever in a late term pregnancy from northern sierra leone with a positive maternal outcome: case report. Hartnett, J. Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever.

    Future Virol. Briese, T. Genetic detection and characterization of Lujo virus, a new hemorrhagic fever—associated Arenavirus from Southern Africa. Gonzalez, J. Mobala virus: biological and physicochemical properties of a new arenavirus isolated in the Central African Republic. Pasteur Virol. Meunier, D. Comparison of Lassa, Mobala, and Ippy virus reactions by immunofluorescence test.

    Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development

    Lancet , — Price, M. A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy. BMJ , — Prevalence and risk factors of Lassa seropositivity in inhabitants of the forest region of Guinea: a cross-sectional study. Weir, M. Bunyaviridae and Arenaviridae—Lassa fever. Goldsmith, C. Modern uses of electron microscopy for detection of viruses. Morphologic differentiation of viruses beyond the family level. Viruses 6 , — El Mekki, A. A comparison of indirect immunofluorescence and electron microscopy for the diagnosis of some haemorrhagic viruses in cell cultures.

    Methods 3 , 61—69 Houlihan, C. Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever. Clinical, epidemiologic, and therapeutic aspects of Lassa fever. Lassa virus infection of rhesus monkeys: pathogenesis and treatment with ribavirin. Frame, J. Clinical features of Lassa fever in Liberia. Viral hemorrhagic fevers—prevention and control.

    Kochhar, D. Effects of exposure to high concentrations of ribavirin in developing embryos. Enria, D. Importance of dose of neutralising antibodies in treatment of Argentine haemorrhagic fever with immune plasma. Lancet 2 , — Maiztegui, J. Efficacy of immune plasma in treatment of Argentine hemorrhagic fever and association between treatment and a late neurological syndrome. The use of Lassa fever convalescent plasma in Nigeria. Leifer, E. Lassa fever, a new virus disease of man from West Africa. Report of a laboratory acquired infection treated with plasma from a person recently recovered from the disease.

    Mendenhall, M. Effective oral favipiravir T therapy initiated after the onset of clinical disease in a model of Arenavirus hemorrhagic fever. Sissoko, D. Experimental treatment with favipiravir for Ebola virus disease the JIKI trial : a historically controlled, single-arm proof-of-concept trial in Guinea.